A low power, microvalve regulated architecture for drug delivery systems
作者： Allan Thomas Evans , Jong M Park , Srinivas Chiravuri , Yogesh B Gianchandani , None
DOI: 10.1007/S10544-009-9372-Y
关键词: Transducer 、 Electronic engineering 、 Wafer 、 Microelectromechanical systems 、 Materials science 、 Bandwidth throttling 、 Miniaturization 、 Automotive engineering 、 Flow control (fluid) 、 Casing 、 Maximum power principle
摘要: This paper describes an actively-controlled architecture for drug delivery systems that offers high performance and volume efficiency through the use of micromachined components. The system uses a controlled valve to regulate dosing by throttling flow from mechanically pressurized reservoir, thereby eliminating need pump. To this end, is fabricated glass wafer silicon-on-insulator sensor integration. draws maximum power 1.68 µW (averaged over time); with existing packaging scheme, it has 2.475 cm3. reservoirs are assembled compressing polyethylene terephthalate polymer balloons metal springs. springs Elgiloy® using photochemical etching. pressurize contents 37 mL chambers up 15 kPa. integrated batteries control circuit board within 113 cm3 casing. been evaluated in different modes mimic clinical applications. Bolus deliveries 1.5 have regulated as well continuous flows 0.15 mL/day accuracies 3.22%. results suggest device can be used implant intrathecal delivery.
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sci-hub.se 参考文章(46)
Nikolai G. Rainov, V. Heidecke1, Management of chronic back and leg pain by intrathecal drug delivery Acta Neurochirurgica. ,vol. 97, pp. 49- 56 ,(2007) , 10.1007/978-3-211-33079-1_6
Zbigniew Zylicz, Aart H Mudde, Painful gynecomastia: an unusual toxicity of gabapentin? Journal of Pain and Symptom Management. ,vol. 20, pp. 2- 3 ,(2000) , 10.1016/S0885-3924(00)00165-2
Kent Sauter, Howard H Kaufman, Stephen M Bloomfield, Sandi Cline, Daniel Banks, None, Treatment of high-dose intrathecal morphine overdose. Case report. Journal of Neurosurgery. ,vol. 81, pp. 143- 146 ,(1994) , 10.3171/JNS.1994.81.1.0143
Dennis W. Coombs, Nora Fine, SPINAL ANESTHESIA USING SUBCUTANEOUSLY IMPLANTED PUMPS FOR INTRATHECAL DRUG INFUSION Anesthesia & Analgesia. ,vol. 73, pp. 226- 231 ,(1991) , 10.1213/00000539-199108000-00019
Chungwoo Kim, Insang Song, Cimoo Song, Changyul Cheon, Youngwoo Kwon, Sukhan Lee, A micromachined cavity resonator for millimeter-wave oscillator applications Sensors and Actuators A: Physical. ,vol. 83, pp. 1- 5 ,(2000) , 10.1016/S0924-4247(00)00302-2
S.C. Jacobsen, R.H. Price, J.E. Wood, T.H. Rytting, M. Rafaelof, A design overview of an eccentric-motion electrostatic microactuator (the wobble motor) Sensors and Actuators. ,vol. 20, pp. 1- 16 ,(1989) , 10.1016/0250-6874(89)87096-9
Arun Paul Amar, Daniel Sullivan, Gutenberg's Bible: Past as Prologue Neurosurgery. ,vol. 44, pp. 2- 4 ,(1999) , 10.1097/00006123-199901000-00002
Samuel J Hassenbusch, Russell K Portenoy, Current Practices in Intraspinal Therapy— A Survey of Clinical Trends and Decision Making Journal of Pain and Symptom Management. ,vol. 20, ,(2000) , 10.1016/S0885-3924(00)00203-7
Ronald M Kanner, Opioids for severe pain: little change over 15 years. Journal of Pain and Symptom Management. ,vol. 21, pp. 3- 3 ,(2001) , 10.1016/S0885-3924(00)00237-2
Sebastiano Mercadante, Russell K. Portenoy, Opioid poorly-responsive cancer pain. Part 1: clinical considerations. Journal of Pain and Symptom Management. ,vol. 21, pp. 144- 150 ,(2001) , 10.1016/S0885-3924(00)00228-1