Imbalanced PTEN and PI3K Signaling Impairs Class Switch Recombination.

摘要: Class switch recombination (CSR) generates isotype-switched Abs with distinct effector functions. B cells express phosphatase and tensin homolog (PTEN) multiple isoforms of class IA PI3K catalytic subunits, including p110α p110δ, whose roles in CSR remain unknown or controversial. In this article, we demonstrate a direct effect PTEN on signaling by acute deletion Pten specifically mature cells, thereby excluding the developmental impact deletion. We show that cell-specific overexpression enhances CSR. More importantly, establish critical role for Furthermore, identify cooperative p110δ suppressing Mechanistically, dysregulation inversely affects activation-induced deaminase expression via modulating AKT activity. Thus, our study reveals balance between is essential to maintain normal