作者: Jia Liu , Karen Dietz , Jacqueline M DeLoyht , Xiomara Pedre , Dipti Kelkar
DOI: 10.1038/NN.3263
关键词: Chromatin 、 Prefrontal cortex 、 Myelin 、 Social isolation 、 Neuroscience 、 Psychology 、 Social relation
摘要: Protracted social isolation of adult mice induced behavioral, transcriptional and ultrastructural changes in oligodendrocytes the prefrontal cortex (PFC) impaired myelination. Social re-integration was sufficient to normalize behavioral changes. Short periods affected chromatin myelin, but did not induce Thus, myelinating PFC respond interaction with changes, suggesting that myelination acts as a form plasticity.