Impaired adult myelination in the prefrontal cortex of socially isolated mice.

作者: Jia Liu , Karen Dietz , Jacqueline M DeLoyht , Xiomara Pedre , Dipti Kelkar

DOI: 10.1038/NN.3263

关键词: ChromatinPrefrontal cortexMyelinSocial isolationNeurosciencePsychologySocial relation

摘要: Protracted social isolation of adult mice induced behavioral, transcriptional and ultrastructural changes in oligodendrocytes the prefrontal cortex (PFC) impaired myelination. Social re-integration was sufficient to normalize behavioral changes. Short periods affected chromatin myelin, but did not induce Thus, myelinating PFC respond interaction with changes, suggesting that myelination acts as a form plasticity.

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