Aberrant DNA methylation of imprinted loci in superovulated oocytes
作者： A. Sato , E. Otsu , H. Negishi , T. Utsunomiya , T. Arima
关键词: Andrology 、 Epigenetics 、 Internal medicine 、 Allele 、 Biology 、 Methylation 、 Endocrinology 、 DNA methylation 、 Gametogenesis 、 Genomic imprinting 、 Oocyte 、 Bisulfite sequencing
摘要: BACKGROUND: There is an increased incidence of rare imprinting disorders associated with assisted reproduction technologies (ARTs). The sex-specific epigenetic modifications that are imposed during gametogenesis act as a primary imprint to distinguish maternal and paternal alleles. most likely candidate for the gametic mark DNA methylation. However, timing methylation acquisition in adult oocytogenesis effects superovulation unknown. METHODS: We examined PEG1(MEST), LIT1(KCNQ10T1) ZAC(PLAGL1) H19 growing oocytes humans mice compared them status mouse neonatal by using bisulphite sequencing. Furthermore, we human mouse. RESULTS: Maternal these genes has already been initiated some extent non-growing but not neonates. In addition, dynamics oocyte development changed more gradually than those development. found demethylation PEG1 from ART-treated infertile women gain H19. also detected changes superovulated mice. CONCLUSION: Our studies suggest can lead production without their correct highlight need research into ARTs.
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