Genetic polymorphism of human plasminogen.

摘要: Using isoelectric focusing (IEF) in polyacrylamide gel of neuraminidase-treated serum or plasma samples and immunofixation caseinolytic overlay after urokinase activation gels, a common genetic polymorphism human plasminogen has been delineated. Two alleles PLGN*A PLGN*B, were observed with gene frequencies whites .69 .30; Orientals .96 .03; blacks .80 .18. Several rare also found. The distribution phenotypes fits the Hardy-Weinberg equilibrium. Inheritance is autosomal codominant expectations Mendelian inheritance. There fetal synthesis, but no transplacental passage either direction.