Race-specific associations of myeloperoxidase with atherosclerosis in a population-based sample: The Dallas Heart Study

摘要: Abstract Objective Myeloperoxidase (MPO) is a leukocyte-derived enzyme that appears to be directly involved in atherosclerosis development. We evaluated the association of circulating MPO with coronary and aortic large, multiethnic population. Methods results Plasma levels were measured 3294 subjects participating Dallas Heart Study, probability-based population sample. Coronary artery calcification (CAC) was by EBCT, abdominal aorta plaque prevalence (AP) burden (APB), as well wall thickness (AWT) determined MRI. Associations between phenotypes assessed multivariable analyses adjusting for traditional risk factors. 4th compared 1st quartile independently associated prevalent AP (OR 1.41, 95% CI 1.08–1.84), APB (beta coefficient 0.23, p =0.02), AWT 0.04, =0.03), but not CAC 0.84, 0.61–1.17). remained after adjustment other inflammatory biomarkers. A significant interaction observed race/ethnicity, ( =0.038), such vs African Americans, 1.81, 1.23–2.65) White or Hispanic participants 0.99, 0.68–1.44). Conclusion Higher atherosclerosis, associations limited American participants. These findings suggest might novel factor contributing racial disparities peripheral vascular disease.