Pca3, pca3 genes, and methods of use

作者: William Brewster Isaacs , Marion J. G. Bussemakers

DOI:

关键词: Nucleic acid methodsAntibodyNucleic acid sequenceBiochemistryMolecular biologyNucleic acidRecombinant DNAAntigenPCA3BiologyGene

摘要: The present invention relates, in general, to a prostate-specific antigen, PCA3. In particular, the relates nucleic acid molecules coding for PCA3 protein; purified proteins and polypeptides; recombinant molecules; cells containing antibodies having binding affinity specifically hybridomas antibodies; probes detection of acids encoding proteins; method detecting or polypeptides sample; kits bioassays using sequence, protein this diagnose, assess, prognose mammal afflicted with prostate cancer; therapeutic uses; methods preventing cancer an animal.

参考文章(169)
James Iwakiri, Kay Grandbois, Nancy Wehner, Howard C.B. Graves, Thomas Stamey, An Analysis of Urinary Prostate Specific Antigen Before and After Radical Prostatectomy: Evidence for Secretion of Prostate Specific Antigen by the Periurethral Glands Journal of Urology. ,vol. 149, pp. 783- 786 ,(1993) , 10.1016/S0022-5347(17)36207-9
Xandra O. Breakefield, Ole Isacson, William S. Rosenberg, Method of gene delivery to post-mitotic cells ,(1992)
W. Scott Grayburn, Thomas L. Sims, Anchored oligo(dT) primers for automated dye terminator DNA sequencing. BioTechniques. ,vol. 25, pp. 340- 346 ,(1998) , 10.2144/98253BM01
Michael K. Brawer, Michael P. Chetner, Jeanette Beatie, David M. Buchner, Robert L. Vessella, Paul H. Lange, Screening for Prostatic Carcinoma with Prostate Specific Antigen The Journal of Urology. ,vol. 147, pp. 841- 845 ,(1992) , 10.1016/S0022-5347(17)37401-3
Kamoi K, Babaian Rj, Advances in the application of prostate-specific antigen in the detection of early-stage prostate cancer. Seminars in Oncology. ,vol. 26, pp. 140- 149 ,(1999)
David A. Dubnau, The Molecular biology of the bacilli Academic Press. ,(1982)
David M. Glover, DNA cloning : a practical approach IRL Press. ,(1985)
Peter Petrusz, Gillian R. Bullock, Techniques in Immunocytochemistry ,(1985)
Paul S. Miller, Paul O.P. Ts'o, Chapter 30. Oligonucleotide Inhibitors of Gene Expression in Living Cells: New Opportunities in Drug Design Annual Reports in Medicinal Chemistry. ,vol. 23, pp. 295- 304 ,(1988) , 10.1016/S0065-7743(08)60858-1