Evidence for a limited role of NAD(P)H in the nutritional regulation of glucagon release: Studies with menadione and NH4Cl
作者： Viviane Leclerq-Meyer , Jocelyne Marchand , Willy J. Malaisse
DOI: 10.1007/BF02582074
关键词: Insulin 、 NAD+ kinase 、 Glucagon 、 Arginine 、 Menadione 、 Biology 、 Endocrinology 、 Internal medicine 、 Islet 、 Glucagon secretion 、 Diabetes mellitus 、 Endocrinology, Diabetes and Metabolism
摘要: Menadione and NH4Cl were reported to lower the islet content of reduced pyridine nucleotides. They used investigate possible significance NAD(P)H in regulation glucagon release by glucose arginine. (10–25 µmol/l) enhanced arginine-stimulated at a low concentration (3.3 mmol/l), but failed both affect secretion sole presence mmol/l) suppress inhibitory action 11.1 mmol/l upon output. In contrast menadione, inhibited concentration. The high was not suppressed NH4Cl. These findings do permit extrapolate A2-cell concept that nucleotides represent major coupling factor nutritional hormonal release.
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