Propofol's effects on nociceptive behavior and spinal C-fos expression afer intraplantar formalin injection in with a mutation in the gamma-aminobutyric acid-typeA β3 subunit

摘要: We investigated whether propofol affected nociceptive behavior and fos-like immunoreactivity (FLI) in the lumbo-sacral spinal cord after intraplantar formalin injection wild-type (WT) mice mutant harboring a point mutation of gamma-aminobutyric acid type(A) receptor, which renders them resistant to propofol. Bolus (30 mg/kg IV) WT reduced phase 1 formalin-evoked over initial 2-3 min but did not alter 2 or FLI (64 +/- 19 cells/section) compared with receiving intralipid vehicle plus (57 cells/section). Most was restricted superficial dorsal horn laminae ipsilateral injection. 60-min infusion were anesthetized throughout display had (58 11 that differ significantly from other groups. Mutant bolus mg/kg) exhibited behavior. The total 47 29 cells/section. These data indicate although produces anesthesia, it does prevent is associated nociception, finding consistent lacking analgesic properties.