Monoclonal antibody to human platelet glycoprotein I. I. Immunological studies.
作者： A. J. McMichael , N. A. Rust , J. R. Pilch , R. Sochynsky , J. Morton
DOI: 10.1111/J.1365-2141.1981.TB07258.X
关键词: Platelet 、 Molecular biology 、 Glycoprotein Ib 、 Antigen 、 Virology 、 Chemistry 、 Bernard–Soulier syndrome 、 Antibody 、 Thrombasthenia 、 Monoclonal antibody 、 Platelet membrane glycoprotein
摘要: A monoclonal hybridoma antibody specific for platelet glycoprotein I complex is described. The nature od the antigen was determined by demonstration that it chymotrypsin sensitive and gave a peak at 150 000 daltons on SDS-PAGE after immunoprecipitation. expression of restricted to platelets megakaryocytes with least 1.6 x 10(4) molecules per platelet. failed bind from patients Bernard Soulier syndrome, where there known be deficiency Ib/Is expression. Binding Glanzmann's thrombasthenia normal.
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