Regenerating Rat Liver: Correlations Between Estrogen Receptor Localization and Deoxyribonucleic Acid Synthesis
作者： Antonio Francavilla , Alfredo Di Leo , Patricia K. Eagon , Shi-Quin Wu , Peter Ove
DOI: 10.1016/S0016-5085(84)80027-X
关键词: Estrogen 、 Endocrinology 、 Receptor 、 Internal medicine 、 Estrogen binding 、 Estrogen receptor activity 、 Hepatectomy 、 Liver regeneration 、 Biology 、 Estrogen receptor 、 Estradiol binding 、 Gastroenterology
摘要: Estrogen receptor activity was quantitated in the cytosol and nucleus of normal rat liver regenerating at several time intervals after 75% hepatectomy. Cytosolic estradiol binding decreases 12, 24, 48 h hepatectomy is 30% that liver. Nuclear estrogen surgery elevated fivefold over values. No alterations affinity for have been observed. Specificity studies indicate receptors from both were similar are highly specific estrogens. These changes cellular distribution parallel increases nuclear deoxyribonucleic acid synthesis mitotic indices
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