Prostate biopsies containing prostate intraepithelial neoplasia and atypical small acinar proliferation: what to do? Biópsias prostáticas contendo neoplasia intraepitelial e proliferação acinar atípica: o que fazer?

摘要: Objective: The aim of the study was to assess frequency high-grade prostate intraepithelial neoplasia and atypical small acinar proliferations on a contemporary series, their relation posterior diagnosis cancer. Methods: A retrospective conducted with 6,490 consecutive men submitted extended biopsies between 2000 2005 at single institution. Of these, 400 (6.16%) had proliferation or prostatic neoplasia, 43 least one follow-up biopsy. results: overall incidence 4.6% 1.4% for proliferation. Highgrade plus occurred in 0.11% men. detection rates cancer repeated were 38.5 53.6% proliferation, respectively. All patients high- grade who biopsy diagnosed There higher risk diagnosing site close previous (OR = 5.93; p 0.015). conclusions: After finding biopsies, is recommended, should be done according clinical data as well. Rebiopsies strongly recommended when association present, found only after second Repeated an always randomized, but sites more extensively sampled.