High-Grade Prostatic Intraepithelial Neoplasia and Atypical Small Acinar Proliferation

摘要: In earlier studies, prostate cancer (PCa) has been reported to appear in 21% 48% of subsequent biopsies for isolated high-grade prostatic intraepithelial neoplasia (PIN) and 34% 60% atypical small acinar proliferation suspicious for, but not diagnostic of, malignancy (ASAP). We report results follow-up a recent cohort community practice patients who underwent biopsy PSA abnormalities. The study group consisted 336 men with initial diagnoses PIN (n = 204), ASAP 78), or both lesions 54) at least one repeat biopsy. Mean intervals months were 6.0 PIN, 3.8 ASAP, 4.9 PIN/ASAP. Follow-up PCa detection rates 23%, 37%, 33%, respectively. predictive value was significantly higher than that (P 0.0188). 23 studies chronologic midpoints the early 1990s, detected mean 36% cases, whereas this after year 2000. 13 on 45% until 1996 39% from 1997 present. PIN/ASAP predicted 33% cases our study, similar alone 0.65) had 44% literature. Factors may account decline values include: 1) extended techniques yield detection, 2) lower rate remaining cancers accompany 3) lack concomitant cancer.