Hedgehog signaling in mature osteoblasts regulates bone formation and resorption by controlling PTHrP and RANKL expression.
作者： Kinglun Kingston Mak , Yanming Bi , Chao Wan , Pao-Tien Chuang , Thomas Clemens
DOI: 10.1016/J.DEVCEL.2008.02.003
关键词: Cell biology 、 Osteoclast 、 Biology 、 Hedgehog signaling pathway 、 RANKL 、 Endocrinology 、 Osteoblast 、 Cellular differentiation 、 Mesenchymal stem cell 、 Bone resorption 、 Cell signaling 、 Internal medicine
摘要: … progenitors during endochondral bone formation. However, … led to increased bone formation and excessive bone resorption… osteoblasts regulates both bone formation and resorption …
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Young-Yun Kong, Hiroki Yoshida, Ildiko Sarosi, Hong-Lin Tan, Emma Timms, Casey Capparelli, Sean Morony, Antonio J. Oliveira-dos-Santos, Gwyneth Van, Annick Itie, Wilson Khoo, Andrew Wakeham, Colin R. Dunstan, David L. Lacey, Tak W. Mak, William J. Boyle, Josef M. Penninger, OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis Nature. ,vol. 397, pp. 315- 323 ,(1999) , 10.1038/16852
R A Nissenson, D Diep, G J Strewler, Synthetic peptides comprising the amino-terminal sequence of a parathyroid hormone-like protein from human malignancies. Binding to parathyroid hormone receptors and activation of adenylate cyclase in bone cells and kidney. Journal of Biological Chemistry. ,vol. 263, pp. 12866- 12871 ,(1988) , 10.1016/S0021-9258(18)37641-5
Pao-Tien Chuang, Andrew P. McMahon, Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein Nature. ,vol. 397, pp. 617- 621 ,(1999) , 10.1038/17611
Philippe Soriano, Generalized lacZ expression with the ROSA26 Cre reporter strain Nature Genetics. ,vol. 21, pp. 70- 71 ,(1999) , 10.1038/5007
Wojtek Auerbach, Wojtek Auerbach, C. Brian Bai, C. Brian Bai, Alexandra L. Joyner, Daniel Stephen, Daniel Stephen, Joon S. Lee, Joon S. Lee, Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway Development. ,vol. 129, pp. 4753- 4761 ,(2002) , 10.1242/DEV.129.20.4753
T. Tsukazaki, A. Ohtsuru, H. Enomoto, H. Yano, K. Motomura, M. Ito, H. Namba, K. Iwasaki, S. Yamashita, Expression of parathyroid hormone-related protein in rat articular cartilage Calcified Tissue International. ,vol. 57, pp. 196- 200 ,(1995) , 10.1007/BF00310258
A Fujimori, S L Cheng, L V Avioli, R Civitelli, Structure-function relationship of parathyroid hormone: activation of phospholipase-C, protein kinase-A and -C in osteosarcoma cells. Endocrinology. ,vol. 130, pp. 29- 36 ,(1992) , 10.1210/ENDO.130.1.1727705
H Juppner, A. Abou-Samra, M Freeman, X. Kong, E Schipani, J Richards, L. Kolakowski, J Hock, J. Potts, H. Kronenberg, al. et, A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide Science. ,vol. 254, pp. 1024- 1026 ,(1991) , 10.1126/SCIENCE.1658941
Patricia Ash, J. F. Loutit, K. M. S. Townsend, Osteoclasts derived from haematopoietic stem cells Nature. ,vol. 283, pp. 669- 670 ,(1980) , 10.1038/283669A0
Lisa V. Goodrich, Ljiljana Milenković, Kay M. Higgins, Matthew P. Scott, Altered Neural Cell Fates and Medulloblastoma in MousepatchedMutants Science. ,vol. 277, pp. 1109- 1113 ,(1997) , 10.1126/SCIENCE.277.5329.1109