S-adenosylmethionine and affective disorder.
作者： Michael W.P. Carney , Brian K. Toone , Edward H. Reynolds
DOI: 10.1016/0002-9343(87)90861-8
关键词: Neuropharmacology 、 Mania 、 Dopaminergic 、 Psychiatry 、 Endogeny 、 Transmethylation 、 Mood 、 Medicine 、 Neurotic Depression 、 Mechanism (biology) 、 Neuroscience
摘要: Several open and double-blind studies suggest that SAMe may have an anti-depressant effect, further are indicated. exert a beneficial effect selectively on endogenous rather than neurotic depression. crosses the blood-brain barrier. is involved in several central enzyme pathways relating to transmethylation folate monoamine metabolism as well membrane function neuro-transmission. The neuropharmacology of SAMe's mood switch mechanism has yet be fully explored. actions dopaminergic system unclear. physiologic substance non-toxic relatively free severe side effects (with exception mania, which manifestation basic disorder.
amjmed.com
elsevier.com
sci-hub.se 参考文章(22)
A. Bertolino, L. Miccoli, V. Porro, Comparison between the antidepressant activity of S-adenosylmethionine (SAMe) and that of some tricyclic drugs. Acta neurologica. ,vol. 33, pp. 243- 255 ,(1978)
T. Bottiglieri, M. W. P. Carney, J. Edeh, M. Laundy, R. Martin, E. H. Reynolds, C. Thomas, B. K. Toone, A Biochemical Study of Depressed Patients Receiving S-Adenosyl-L-Methionine (SAM) Humana Press. pp. 327- 338 ,(1986) , 10.1007/978-1-4612-5012-8_27
Renato D. Alarcon, Lelland C. Tolbert, John A. Monti, Donna A. Morere, William G. Walter-Ryan, Beverly Kemp, John R. Smythies, One-carbon metabolism disturbances in affective disorders. A preliminary report. Journal of Affective Disorders. ,vol. 9, pp. 297- 301 ,(1985) , 10.1016/0165-0327(85)90060-6
G.L. Cantoni, Methylation of nicotinamide with a soluble enzyme system from rat liver. Journal of Biological Chemistry. ,vol. 189, pp. 203- 216 ,(1951) , 10.1016/S0021-9258(18)56110-X
CHRISTOPHER S. THOMAS, TEODORO BOTTIGLIERI, JAMES EDEH, M W P CARNEY, E H REYNOLDS, B K TOONE, The influence of S-adenosylmethionine (SAM) on prolactin in depressed patients. International Clinical Psychopharmacology. ,vol. 2, pp. 97- 102 ,(1987) , 10.1097/00004850-198704000-00001
M.W.P. Carney, Rodger Martin, Teodoro Bottiglieri, E.H. Reynolds, Hilary Nissenbaum, B.K. Toone, B.F. Sheffield, SWITCH MECHANISM IN AFFECTIVE ILLNESS AND S-ADENOSYLMETHIONINE The Lancet. ,vol. 321, pp. 820- 821 ,(1983) , 10.1016/S0140-6736(83)91876-7
M. W.P. Carney, E. H. Reynolds, B. Toone, R. Martine, H. Nissenbaum, FOLIC ACID, S-ADENOSYL METHIONINE AND AFFECTIVE DISORDER Clinical Neuropharmacology. ,vol. 7, ,(1984) , 10.1097/00002826-198406001-00052
A. Agnoli, V. Andreoli, M. Casacchia, R. Cerbo, Effect of S-Adenosyl-L-Methionine (SAMe) upon depressive symptoms Journal of Psychiatric Research. ,vol. 13, pp. 43- 54 ,(1976) , 10.1016/0022-3956(76)90008-X
E. H. REYNOLDS, B. B. GALLAGHER, R. H. MATTSON, M. BOWERS, A. L. JOHNSON, Relationship between serum and cerebrospinal fluid folate. Nature. ,vol. 240, pp. 155- 157 ,(1972) , 10.1038/240155A0
M. W. P. Carney, James Edeh, Teodoro Bottiglieri, E. M. Reynolds, B. K. Toone, Affective illness and S-adenosyl methionine: a preliminary report. Clinical Neuropharmacology. ,vol. 9, pp. 379- 385 ,(1986) , 10.1097/00002826-198608000-00005