Dietary polyphenols suppress chronic inflammation by modulation of multiple inflammation-associated cell signaling pathways

摘要: Abstract The high failure rate of the reductionist approach to discover effective and safe drugs treat chronic inflammatory diseases has led scientists seek alternative ways. Recently, targeting cell signaling pathways been utilized as an innovative drug leads from natural products. Cell mechanisms have identified playing key role in diverse by inducing proliferation, survival apoptosis. Phytochemicals are known be able modulate cellular molecular networks which associated including cancer-associated inflammation. In this review, roles dietary polyphenols (apigenin, kaempferol, quercetin, curcumin, genistein, isoliquiritigenin, resveratrol gallic acid) modulating multiple inflammation-associated deliberated. Scientific databases on suppressive effects inflammation via modulation especially recent five years gathered critically analyzed. several pathways, namely nuclear factor-kappa β (NF-κB), mitogen activated protein kinases (MAPKs), Wnt/β-catenin phosphatidylinositol 3-kinase kinase B (PI3K/Akt) selective actions various components networks. reveal their potential use prevention treatment disorders. Understanding mechanistic involved is necessary for lead identification development future functional foods diseases.