G protein coupled growth factor receptor tyrosine kinase: no longer an oxymoron
作者： Pradipta Ghosh
DOI: 10.1080/15384101.2015.1066538
关键词: Receptor Protein-Tyrosine Kinases 、 Receptor tyrosine kinase 、 G protein-coupled receptor 、 Biology 、 Cell biology 、 Heterotrimeric G protein 、 G protein-coupled receptor kinase 、 GTPase-activating protein 、 G protein 、 Signal transduction
摘要: Environmental cues are transmitted to the interior of cell via a complex network signaling hubs. Receptor tyrosine kinases (RTKs) and trimeric G proteins 2 such major hubs in eukaryotes. Canonical signal transduction is spatially temporally restricted, i.e., triggered exclusively at plasma membrane (PM) by agonist activation G-protein-coupled receptors (GPCRs) process that completes within few hundred milliseconds. Recently, rapidly emerging paradigm has revealed non-canonical pathway for non-receptor GEF, GIV/Girdin, distinctive temporal spatial features. Such can be multiple growth factor RTKs, occur PM on internal membranes discontinuous with PM, continue prolonged periods time. The molecular mechanisms govern protein relevance this new health disease discussed.
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