Regulation of the immune response by antibody

摘要: Abstract The ability of different classes passively administered guinea pig antibody (γ1, γ2, and IgM) to regulate humoral cell-mediated immunity flagellin, polymerized flagellin (POL), sheep red blood cells (SRBC) was investigated in rats. It found that at high concentrations, all suppressed the primary responses usually enhanced delayed-type hypersensitivity induced by three antigens. With SRBC, passive varied their suppressing enhancing properties, being order: γ2 > γ1 = IgM. At low IgM response delayed flagellin. Such an effect not observed with either POL or SRBC. Priming for a secondary less readily antibody. removal macrophage cytophilic from converted this preparation (γ2 absorbed) which had effects on approaching These results indicated immunological according physical nature antigen injected. Furthermore, it appears differences regulatory properties various are dependent upon content In addition, obtained support notion inverse relationship exists between immunity.