Mucus and the Goblet Cell

摘要: The discovery of an inner mucus layer normally impervious to bacteria has changed our way understanding the interaction between commensal and host epithelial cells. This colon is rapidly renewed converted into outer by controlled endogenous proteolytic processing. characteristics esteem from properties main protein component these layers, MUC2 mucin. forms enormously large net-like structure that builds laminated largely acts as a size exclusion filter excluding bacteria. In absence mucin, there no reach cell surface, penetrate crypts are also found inside cells, something leads severe inflammation. Other mouse models spontaneously develop colitis due different defects, like absent ion channel (Nhe3) or immunological mediators (Tlr5, IL-10), all have defective layer. Human patients with active ulcerative this penetrable beads Some in remission normal whereas others Together, suggests its integrity important for protection epithelium inhibiting activation immune system colitis.