Highly enantioselective transfer hydrogenation catalyzed by diasteromeric mixtures of axially chiral (aR,S)- and (aS,S)-Biscarbolines
作者： Huajie Zhu , Zhenqiu Li , Longfei Li , Mengxian Dong , Shengnan Li
DOI: 10.1016/J.TET.2021.131924
关键词: Enantioselective synthesis 、 Chemistry 、 Transfer hydrogenation 、 Reaction conditions 、 Organic chemistry 、 Catalysis 、 Axial symmetry
摘要: Abstract The mixtures of axially chiral (aR,S)- and (aS,S)-biscarboline alcohols were firstly used as catalysts in enantioselective 1,2- 1,4-transfer hydrogenations ketimines β-enamino esters, respectively. This mixed exhibited excellent enantioselectivity (up to 98%ee) the transfer under mild reaction conditions.
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