Overexpression of STAT1 suppresses angiogenesis under hypoxia by regulating VEGF‑A in human glioma cells.

作者: Yunsheng Zhang , Guishan Jin , Junwen Zhang , Ruifang Mi , Yiqiang Zhou

DOI: 10.1016/J.BIOPHA.2018.05.079

关键词: GliomaHypoxia (medical)Tube formationSTAT proteinSTAT1AngiogenesisChemistryCell growthVascular endothelial growth factor ACancer research

摘要: … responses, cell cycle, cell survival and angiogenesis [5,6]. … However, whether and by what mechanism STAT1 functions in … U251 and U373 human glioblastoma multiforme cell lines …

参考文章(33)
Folkman J, The role of angiogenesis in tumor growth. Seminars in Cancer Biology. ,vol. 3, pp. 65- 71 ,(1992)
Adrian L. Harris, Hypoxia — a key regulatory factor in tumour growth Nature Reviews Cancer. ,vol. 2, pp. 38- 47 ,(2002) , 10.1038/NRC704
Hua Yu, Richard Jove, The STATs of cancer — new molecular targets come of age Nature Reviews Cancer. ,vol. 4, pp. 97- 105 ,(2004) , 10.1038/NRC1275
Tumor Angiogenesis: A Quantitative Method for Histologic Grading Journal of the National Cancer Institute. ,vol. 48, pp. 347- 356 ,(1972) , 10.1093/JNCI/48.2.347
Balaram Thota, Arivazhagan Arimappamagan, Thennarasu Kandavel, Arun H. Shastry, Paritosh Pandey, Bangalore Ashwathnarayanarao Chandramouli, Alangar Sathyaranjandas Hegde, Paturu Kondaiah, Vani Santosh, STAT-1 expression is regulated by IGFBP-3 in malignant glioma cells and is a strong predictor of poor survival in patients with glioblastoma Journal of Neurosurgery. ,vol. 121, pp. 374- 383 ,(2014) , 10.3171/2014.4.JNS131198
Adaia Albasanz-Puig, Jacqueline Murray, Mayumi Namekata, Errol S Wijelath, None, Opposing roles of STAT-1 and STAT-3 in regulating vascular endothelial growth factor expression in vascular smooth muscle cells. Biochemical and Biophysical Research Communications. ,vol. 428, pp. 179- 184 ,(2012) , 10.1016/J.BBRC.2012.10.037
Haitao Ju, Xin Li, Hong Li, Xiaojuan Wang, Hongwei Wang, Yang Li, Changwu Dou, Gang Zhao, Mediation of multiple pathways regulating cell proliferation, migration, and apoptosis in the human malignant glioma cell line U87MG via unphosphorylated STAT1: laboratory investigation. Journal of Neurosurgery. ,vol. 118, pp. 1239- 1247 ,(2013) , 10.3171/2013.3.JNS122051
Johannes Schödel, Spyros Oikonomopoulos, Jiannis Ragoussis, Christopher W. Pugh, Peter J. Ratcliffe, David R. Mole, High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq Blood. ,vol. 117, ,(2011) , 10.1182/BLOOD-2010-10-314427
H Harada, S Kizaka-Kondoh, G Li, S Itasaka, K Shibuya, M Inoue, M Hiraoka, Significance of HIF-1-active cells in angiogenesis and radioresistance. Oncogene. ,vol. 26, pp. 7508- 7516 ,(2007) , 10.1038/SJ.ONC.1210556
Michael J Gray, Jing Zhang, Lee M Ellis, Gregg L Semenza, Douglas B Evans, Stephanie S Watowich, Gary E Gallick, HIF-1α, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas Oncogene. ,vol. 24, pp. 3110- 3120 ,(2005) , 10.1038/SJ.ONC.1208513