A method for the covalent capture and screening of diverse small molecules in a microarray format.
作者： James E Bradner , Olivia M McPherson , Angela N Koehler
关键词: Systems biology 、 Proteomics 、 Computational biology 、 Drug design 、 Chemical compound microarray 、 Biology 、 Drug discovery 、 Structural biology 、 Small molecule 、 DNA microarray
摘要: … for printing diverse small molecules in microarray format and screening both purified proteins and complex mixtures. Using this platform, we have detected small molecule binders for …
nature.com
sci-hub.se 参考文章(17)
Gavin MacBeath, Angela N. Koehler, Stuart L. Schreiber, Printing Small Molecules as Microarrays and Detecting Protein−Ligand Interactions en Masse Journal of the American Chemical Society. ,vol. 121, pp. 7967- 7968 ,(1999) , 10.1021/JA991083Q
Iva Navratilova, Marianna Dioszegi, David G. Myszka, Analyzing ligand and small molecule binding activity of solubilized GPCRs using biosensor technology. Analytical Biochemistry. ,vol. 355, pp. 132- 139 ,(2006) , 10.1016/J.AB.2006.04.021
Felice Lu, Seung-Wook Chi, Do-Hyoung Kim, Kyou-Hoon Han, Irwin D. Kuntz, R. Kiplin Guy, Proteomimetic Libraries: Design, Synthesis, and Evaluation of p53−MDM2 Interaction Inhibitors ACS Combinatorial Science. ,vol. 8, pp. 315- 325 ,(2006) , 10.1021/CC050142V
Maja Köhn, Ron Wacker, Carsten Peters, Hendrik Schröder, Laurent Soulère, Rolf Breinbauer, Christof M. Niemeyer, Herbert Waldmann, Staudinger-Ligation: A new Immobilization Strategy for the Preparation of Small Molecule Arrays Angewandte Chemie. ,vol. 42, pp. 5830- 5834 ,(2003) , 10.1002/ANIE.200352877
Li Peng, Ruiwu Liu, Jan Marik, Xiaobing Wang, Yoshikazu Takada, Kit S Lam, Combinatorial chemistry identifies high-affinity peptidomimetics against α4β1 integrin for in vivo tumor imaging Nature Chemical Biology. ,vol. 2, pp. 381- 389 ,(2006) , 10.1038/NCHEMBIO798
Terence Keenan, David R. Yaeger, Nancy L. Courage, Carl T. Rollins, Mary Ellen Pavone, Victor M. Rivera, Wu Yang, Tao Guo, Jane F. Amara, Tim Clackson, Michael Gilman, Dennis A. Holt, Synthesis and activity of bivalent FKBP12 ligands for the regulated dimerization of proteins Bioorganic & Medicinal Chemistry. ,vol. 6, pp. 1309- 1335 ,(1998) , 10.1016/S0968-0896(98)00125-4
Paul A Clemons, Brian G Gladstone, Abhinav Seth, Elizabeth D Chao, Michael A Foley, Stuart L Schreiber, Synthesis of Calcineurin-Resistant Derivatives of FK506 and Selection of Compensatory Receptors Chemistry & Biology. ,vol. 9, pp. 49- 61 ,(2002) , 10.1016/S1074-5521(02)00085-6
Benjamin T Houseman, Milan Mrksich, Carbohydrate Arrays for the Evaluation of Protein Binding and Enzymatic Modification Chemistry & Biology. ,vol. 9, pp. 443- 454 ,(2002) , 10.1016/S1074-5521(02)00124-2
Mahesh Uttamchandani, Daniel P. Walsh, Sonya M. Khersonsky, Xuan Huang, Shao Q. Yao, Young-Tae Chang, Microarrays of Tagged Combinatorial Triazine Libraries in the Discovery of Small-Molecule Ligands of Human IgG ACS Combinatorial Science. ,vol. 6, pp. 862- 868 ,(2004) , 10.1021/CC049900S
Paul J. Hergenrother, Kristopher M. Depew, Stuart L. Schreiber, Small-Molecule Microarrays: Covalent Attachment and Screening of Alcohol-Containing Small Molecules on Glass Slides Journal of the American Chemical Society. ,vol. 122, pp. 7849- 7850 ,(2000) , 10.1021/JA0014032