Genesis of Neuronal and Glial Progenitors in the Cerebellar Cortex of Peripuberal and Adult Rabbits

摘要: Adult neurogenesis in mammals is restricted to some brain regions, contrast with other vertebrates which the genesis of new neurons more widespread different areas nervous system. In mammalian cerebellum, thought be limited early postnatal period, coinciding end granule cell and disappearance external layer (EGL). We recently showed that rabbit cerebellum EGL replaced by a proliferative called ‘subpial layer’ (SPL) persists beyond puberty on cerebellar surface. Here we investigated what happens cortex peripuberal rabbits using endogenous exogenously-administered proliferation antigens association cohort typical markers for neurogenesis. show cortical progenitors extensively continue generated herein. Surprisingly, this neurogenic process continues lesser extent adult, even absence SPL. describe two populations newly cells, involving neuronal cells multipolar, glia-like cells. The precursors molecular layer, giving rise immunoreactive GABA, transcription factor Pax2, marker GABAergic interneuronal neuroepithelial origin ascend through white matter during development. multipolar are Map5+, contain Olig2 Sox2 factors, detectable all layers. Some dividing Sox2+ Bergmann glia All independent from SPL genesis, latter ending before puberty. This study reveals adult can exist mammals. Since have longer lifespan than rodents, protracted within its parenchyma could suitable model studying tissue permissiveness