Replacement of mammalian auditory hair cells.
作者： Azel Zine , François de Ribaupierre
DOI: 10.1097/00001756-199801260-00016
关键词: Mitosis 、 Cell biology 、 In vitro 、 Inner ear 、 Hair cell 、 Cochlea 、 Epidermal growth factor 、 Pathology 、 Regeneration (biology) 、 Growth factor 、 Biology
摘要: We investigated the potential for hair cell regeneration in neonatal rat organs of Corti grown culture following destruction cells by neomycin toxicity. Replacement were observed light and scanning electron microscopy lesion sites cultures treated with transforming growth factor-alpha, epidermal factor or a combination both factors 5-7 days post-injury. These new had morphological characteristics immature cells. Autoradiographic localization [3H]thymidine-labelled on semi-thin sections indicated that these replacement did not arise through renewed mitotic division, although an important proliferation was outside area supporting sensory
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