Altered Fecal Microbiota Composition Associated with Food Allergy in Infants
作者： Zongxin Ling , Zailing Li , Xia Liu , Yiwen Cheng , Yueqiu Luo
DOI: 10.1128/AEM.00003-14
关键词: Microbiology 、 Dysbiosis 、 Firmicutes 、 Proteobacteria 、 Bacteroidetes 、 Bacteroides 、 Clostridiaceae 、 Biology 、 Clostridium 、 Actinobacteria
摘要: Increasing evidence suggests that perturbations in the intestinal microbiota composition of infants are implicated pathogenesis food allergy (FA), while actual structure and human beings with FA remain unclear. Microbial diversity were analyzed parallel barcoded 454 pyrosequencing targeting 16S rRNA gene hypervariable V1-V3 regions feces 34 (17 IgE mediated 17 non-IgE mediated) 45 healthy controls. Here, we showed several key FA-associated bacterial phylotypes, but not overall diversity, significantly changed infancy fecal associated development FA. The proportion abundant Bacteroidetes, Proteobacteria, Actinobacteria phyla reduced, Firmicutes phylum was highly enriched group (P < 0.05). Abundant Clostridiaceae 1 organisms prevalent at family level = 0.016). FA-enriched phylotypes negatively correlated interleukin-10, for example, genera Enterococcus Staphylococcus. Despite profound interindividual variability, levels 20 predominant different between control groups Infants IgE-mediated had increased Clostridium sensu stricto Anaerobacter decreased Bacteroides XVIII A positive correlation observed serum-specific (R 0.655, P 0.001). specific signature could distinguish from non-IgE-mediated ones. Detailed analysis a well-characterized cohort dysbiosis may play pathogenic role
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