Ketoconazole, an oral antifungal: laboratory and clinical assessment of imidazole drugs.

摘要: Miconazole, a parenterally administered imidazole antifungal agent has been shown to produce responses in systemic fungal infections man. Ketoconazole, an analogue, can be given by mouth. It is inhibitory vitro at low concentrations most fungi. Blood levels after oral administration animals and man greatly exceed these for several hours. The efficacy of this drug demonstrated animal models. Initial clinical evaluation produced therapy with 200-400 mg/day 13 16 evaluable patients superficial infections, involving 10 pathogens. No toxicity noted date human studies. Ketoconazole promising needing further extensive evaluation.