Thyroid Hormone Receptor Family Members
作者： Ronald N. Cohen , Fredric E. Wondisford
DOI: 10.1007/978-1-59259-221-0_8
关键词: Response element 、 Cell biology 、 Nuclear receptor 、 Thyroid-stimulating hormone 、 Transcription factor 、 Parathyroid hormone receptor 、 Thyroid hormone resistance 、 Thyroid hormone receptor beta 、 Thyroid hormone receptor 、 Chemistry
摘要: The thyroid hormone receptor (TR) is a member of the nuclear (NHR) superfamily. These receptors are hormone-dependent transcription factors that regulate gene by binding to regulatory regions DNA termed response elements (HREs) (1). TR binds in presence or absence its ligand, triiodothyronine (T3), and capable upregulating downregulating depending on nature underlying element. Genes stimulated T3 regulated positive (pTREs); genes repressed negative (nTREs). nTREs particularly important feedback inhibition hypothalamic-pituitary-thyroid axis, present promoter TRH, stimulating β (TSHβ), common pituitary glycoprotein α-subunit genes. TREs as monomer, homodimer, heterodimer with accessory proteins (TRAPs). In addition, other proteins, including corepressors coactivators, which enable it modulate T3-dependent Thus, associated factors, well element, enables expression differentially.
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