MicroRNAs MiR-218, MiR-125b, and Let-7g Predict Prognosis in Patients with Oral Cavity Squamous Cell Carcinoma

摘要: MicroRNAs (miRNAs) have a major impact on regulatory networks in human carcinogenesis. In this study, we sought to investigate the prognostic significance of miRNAs patients with oral cavity squamous cell carcinoma (OSCC). discovery phase, RNA was extracted from 58 OSCC tumor samples and paired normal tissues. MiRNAs expression evaluated TaqMan Array Card MicroRNA assays. The miRNA signature identified phase validated by qRT-PCR replication set consisting 141 formalin-fixed, paraffin-embedded (FFPE) samples. We network centered three hub genes (SP1, MYC, TP53) that predicted distinct clinical endpoints. Three (miR-218, miR-125b, let-7g) their downstream response had concordant disease-free survival disease-specific rates. addition, reduced miR-218, let-7g higher risk poor outcomes presence specific factors (p-stage III-IV, pT3-4, or pN+). Our findings indicate may improve stratification over traditional factors.