The role of endocytic Rab GTPases in regulation of growth factor signaling and the migration and invasion of tumor cells

摘要: Metastasis is characterized pathologically by uncontrolled cell invasion, proliferation, migration and angiogenesis. It a multistep process that encompasses the modulation of membrane permeability spreading, proliferation extracellular matrix, increase in adhesion molecules interaction, decrease attachment induced survival signals propagation nutrient supplies (blood vessels). In cancer, solid tumor cannot expand spread without series synchronized events. Changes receptor (e.g., integrins, cadherin-catenins) protease expressions have been linked to invasion metastasis. has also determined ligand-growth factor interactions associated with cancer development metastasis via endocytic pathway. Specifically, growth factors, which include IGF-1 IGF-2 therapy, most if not all features this review, we will revisit some key findings on perhaps one important hallmarks metastasis: role pathway mediating phenomenon.