Smooth muscle relaxant activity of Crocus sativus (saffron) and its constituents: possible mechanisms.
作者： Mohammad Hossein Boskabady , Mohammad Reza Khazdair , Amin Mokhtari-Zaer
关键词: Safranal 、 Crocetin 、 Crocin 、 Histamine 、 Nitric oxide 、 Traditional medicine 、 Medicine 、 Stomach disorder 、 Crocus sativus 、 Kaempferol
摘要: Saffron, Crocus sativus L. (C. sativus) is rich in carotenoids and used traditional medicine for treatment of various conditions such as coughs, stomach disorders, amenorrhea, asthma cardiovascular disorders. These therapeutic effects the plant are suggested to be due its relaxant effect on smooth muscles. The C. constituents different muscles underlying mechanisms have been studied. Several studies shown including safranal, crocin, crocetin kaempferol blood vessels. In addition, it was reported that saffron stigma lowers systolic pressure. present review highlights possible this relaxing activation s2-adrenoceptors, inhibition histamine H1 muscarinic receptors calcium channels modulation nitric oxide (NO) also reviewed.
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