25-Hydroxyvitamin D levels in serum at the onset of multiple sclerosis.
作者： M Soilu-Hänninen , L Airas , I Mononen , A Heikkilä , M Viljanen
DOI: 10.1191/1352458505MS1157OA
关键词: Bone remodeling 、 Multiple sclerosis 、 Endocrinology 、 Central nervous system disease 、 Internal medicine 、 Vitamin D and neurology 、 Risk factor 、 Metabolism 、 Immune system 、 Reference range 、 Medicine
摘要: Past sun exposure and vitamin D supplementation have been associated with a reduction in the risk of MS. We measured serum concentration 25-hydroxyvitamin (25[OH]D) at time MS diagnosis 40 patients controls. found no difference levels 25(OH)D between controls when all samples or obtained during winter months were compared, but had significantly lower concentrations June to September than The stores adequate for bone metabolism (> 37 nmol/L) 70% throughout year within hypovitaminosis level (< 30% some year. During MS-relapses, remission, mostly reference range observed relation normal metabolism. conclude that most are their However, relapses remission suggest could be involved regulation clinical disease activity optimal immune responses remain determined.
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