Changes of vitamin D3 serum concentrations at the onset of immune-mediated type 1 (insulin-dependent) diabetes mellitus.

摘要: Several hormones such as 1,25-dihydroxy-vitamin D3 (1,25-(OH)2D3), alpha-MSH, or ACTH have been found to interact extensively with the immune system. In view of immune-mediated nature Type 1 (insulin-dependent) diabetes mellitus, 49 recently diagnosed diabetic patients were investigated in terms serum 1,25-(OH)2D3-levels, 25-hydroxyvitamin D3(25-(OH)D3), alpha-MSH and ACTH, compared 42 healthy controls. A marked decrease 1,25-(OH)2D3-levels was at onset normal controls (39 +/- 2 vs 55 4 pg/ml, p less than 0.01). Grouping according season (winter summer) blood sampling, it demonstrated that 1,25-(OH)2D3 primarily present during summer due a loss seasonal rhythm this hormone observed (summer: 41 63 0.001; winter: 37 3 33 n.s.). Serum concentrations 25-(OH)D3 closely correlated those 1,25-(OH)2D3, both (r = 0.55, 0.002) 0.41, 0.05), yielding similar variation also vitamin metabolite patients. No difference mean median values between IDDM controls, although exhibited much higher levels did controls.(ABSTRACT TRUNCATED AT 250 WORDS)