1,25-Dihydroxyvitamin D3 reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis
作者： M. T. Cantorna , C. E. Hayes , H. F. DeLuca
关键词:
摘要: Experimental autoimmune encephalomyelitis (EAE) is an disease believed to be a model for the human multiple sclerosis (MS). Induced by immunizing B10.PL mice with myelin basic protein (MBP), EAE was completely prevented administration of 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3]. 1,25-(OH)2D3 could also prevent progression when administered at appearance first disability symptoms. Withdrawal resulted in resumption EAE. Thus, block reversible. A deficiency vitamin D increased susceptibility or its analogs are potentially important treatment MS.
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