The 4-O-Methylation pathway of catecholamines: Search for an in vivo production of 3-hydroxy,4-methoxyphenylglycol(iso-MHPG)
作者： Pierre Mathieu , Jacques Greffe , Marie-Odile Pharaboz , Daniel Deruaz , Roger Guilluy
DOI: 10.1016/0009-8981(80)90148-5
关键词: Norepinephrine 、 Urinary system 、 Internal medicine 、 Chemistry 、 Dopamine 、 In vivo 、 Chromatography 、 Excretion 、 Electron capture detector 、 Nervous tissue 、 Endocrinology 、 Methylation 、 Clinical biochemistry 、 Biochemistry 、 Biochemistry, medical 、 General Medicine
摘要: The existence of 3-hydroxy,4-methoxyphenylglycol in biological fluids has been investigated. 4-Hydroxy,3-methoxy-phenylglycol (MHPG) and (iso-MHPG) have separated from each other by gas-liquid chromatography their heptafluorobutyryl derivatives, using an electron capture detector procedure. Urines normal subjects, patients with secreting nervous tissue tumors human cerebrospinal were analyzed. Iso-MHPG was never detected, the exception trace amounts one urinary sample a patient peculiarly high excretion MHPG. It is concluded that norepinephrine probably not 4-O-methylated vivo, contrary to dopamine which known lead, at least small extent, metabolites.
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