Les metabolites des catécholamines: L'acide 3-hydroxy, 4-méthoxyphénylacétique (acide homoiso-vanillique, iso-HVA) dans les milieux biologiques: Urine, liquide céphalo-rachidien, tissu cérébral

摘要: Resume Homo-isovanillic acid (3-hydroxy,4-methoxyphenylacetic acid, iso-HVA) and homovanillic (HVA) have been studied in urine, cerebrospinal fluid brain, by means of bidimensional paper Chromatographic separation their azo-derivatives with diazotized para-nitroaniline. was present each 37 urine samples analysed. The urinary iso-HVA/HVA ratio found to be 7.2 ± 2.5%. This value indicates that the daily excretion iso-HVA healthy subjects ranges from about 0.30 0.60 mg. seems usually human CSF. In brain (from animal: sheep), highest level homo-isovanillic is caudate nucleus, an 53–58%; mean eight determinations: 56%. observation agrees previous suggestion authors dopamine undergoes partial para- O -methylation a point which interest respect possible psychiatric implication this new pathway. view this, three C.S.F. schizophrenic patients after l -dopa load.