Medium‐dose ultraviolet (UV) A1 vs. narrowband UVB phototherapy in atopic eczema: a randomized crossover study

摘要: Summary Background  Ultraviolet (UV) A1 and narrowband (NB)-UVB have been reported to be effective treatments for atopic eczema (AE). Objectives  We aimed compare the efficacy of medium-dose UVA1 NB-UVB mono-phototherapy in patients with AE. Methods  A randomized double-blind controlled crossover trial (ClinicalTrials.gov Identifier: NCT00419406) was conducted which AE received a 6-week course both NB-UVB. Clinical assessed using Six Area, Sign, Atopic Dermatitis (SASSAD) score visual analogue scale pruritus. Assessment health-related quality life performed Skindex-29. Total immunoglobulin E (IgE) eosinophilic cationic protein (ECP) were evaluated at baseline after each phototherapy course. Results  Twenty-eight who completed courses on an intention-to-treat basis analysed according design. Both interventions associated significant clinical improvement but there no difference between respect mean ± SD relative reduction (RR) scores (SASSAD, 43·7 ± 31·4% vs. 39·4 ± 24·1%, P = 0·5; pruritus score, 16 ± 61·8% 25·2 ± 30·5%, P = 0·5, respectively). There RR Skindex-29 (12·7 ± 18·8% 16·5 ± 17·6%, P = 0·1). Changes total IgE ECP levels following did not differ significantly (P = 0·3 P = 0·9, respectively). Conclusions  resulted improvement. With regard tolerability, phototherapeutic modalities may considered comparably good.