Comparison of different activity parameters in atopic dermatitis: correlation with clinical scores

摘要: SummaryBackground Several laboratory markers have been described to correlate positively with disease activity of atopic dermatitis (AD). These include soluble adhesion molecules and eosinophil granular proteins. Although the correlation these parameters severity extent skin involvement has repeatedly studied in past, no systematic investigation performed over a lengthy period time. In addition, subjective recorded by patient included studies dealing activity. Objectives To assess validity different objective [soluble E-selectin (sE-selectin), vascular cell molecule-1 (sVCAM-1), cationic protein (ECP), urinary nitrate excretion (reflecting endogenous nitric oxide formation) patients' impressions pruritus, sleeplessness status] as AD activity. Methods Twenty patients were examined for 1 year their status was evaluated an established score (SCORAD). sE-selectin, sVCAM-1 ECP analysed commercial test kits. Urinary concentration measured gas chromatography-mass spectrometry. The parameters, impression status, on visual analogue scale. Results In this long-term trial, only sE-selectin showed statistically significant SCORAD score. Conclusions Our data indicate that basic clinical scoring remains most effective relevant method recording AD.