Barbering (fur and whisker trimming) by laboratory mice as a model of human trichotillomania and obsessive-compulsive spectrum disorders.

摘要: Animal diseases that develop spontaneously in a limited subpopulation can provide powerful models of human disease because they means to investigate the interaction broad range biological and environmental etiologic processes. In contrast, with experimentally induced animal models, etiology model is inherently fixed, only speak subset those involved disease. 'Barbering' (abnormal whisker- fur-plucking behavior) mice resembles trichotillomania (compulsive hair plucking) barbering pluck focused areas hair, engage post-plucking manipulatory oral behaviors. We performed cross-sectional epidemiologic survey population 2,950 laboratory further assess face validity as spontaneous trichotillomania. Patterns loss demographic risk factors were recorded for each mouse, analyzed by use logistic regression. Barbering paralleled terms phenomenology, demography, etiology. Thus, similar trichotillomania, barbers predominately plucked from scalp around eyes genitals; was female biased, had its onset during puberty; included reproductive status genetic background. Therefore, has excellent may represent refined non-invasive model, especially studies complex genetic/environmental etiologies this disorder.