Cytokine receptors and signal transduction
作者： Atsushi Miyajima , Toshio Kitamura , Nobuyuki Harada , Takashi Yokota , Ken-ichi Arai
DOI: 10.1146/ANNUREV.IY.10.040192.001455
关键词: Cytokine binding 、 Signal transduction 、 Receptor 、 Biology 、 Tyrosine kinase 、 Tyrosine kinase 2 、 Cell biology 、 Glycoprotein 130 、 Janus kinase 1 、 Platelet-derived growth factor receptor
摘要: Cytokines play a vital role in coordinating immune and inflammatory re sponses. Unlike growth factor receptors with tyrosine kinase, cytokine have no intrin sic kinase activity. Based on their struc ture, are classified into several groups. High affinity recep tors for IL-2, IL-3, IL-5, IL-6, GM-CSF composed of at least two distin ct subunits, C( {3. The subunits primary binding proteins, the {3 required mation high
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