Protective effect of Heliotropium foertherianum (Boraginaceae) folk remedy and its active compound, rosmarinic acid, against a Pacific ciguatoxin.
作者： Fanny Rossi , Valérie Jullian , Ralph Pawlowiez , Shilpa Kumar-Roiné , Mohamed Haddad
DOI: 10.1016/J.JEP.2012.05.045
关键词: Biochemistry 、 Active compound 、 Heliotropium foertherianum 、 Rosmarinic acid 、 Ciguatoxin 、 Traditional medicine 、 Bioassay 、 Brevetoxin 、 Caffeic acid 、 Biology 、 Boraginaceae
摘要: Abstract Ethnopharmacological relevance Senescent leaves of Heliotropium foertherianum Diane & Hilger (Boraginaceae) are traditionally used in the Pacific region to treat Ciguatera Fish Poisoning. This plant contains rosmarinic acid that is known for its multiple biological activities. In present study, H. aqueous extract, and derivatives were evaluated their capacity reduce effect ciguatoxins. Materials methods Aqueous extract was prepared studied effects against a ciguatoxin (P-CTX-1B) neuroblastoma cell assay receptor binding assay. Rosmarinic six also by means these bioassays. For this purpose, we have developed an improved synthetic route caffeic 3,4-dihydroxy-phenethyl ester (CADPE). Results Both showed inhibitory activities above Among all molecules evaluated, most active compound. Conclusion These results confirm further potential treatment
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