GH secretion status in myotonic dystrophy
作者： J.M. Gómez-Sáez , J.M. Fernández-Real , M.A. Navarro , J.A. Martínez-Matos , J. Soler
DOI: 10.1016/0306-4530(93)90003-4
关键词: Abnormal Growth Hormone 、 Growth hormone secretion 、 Hypoglycemia 、 Pyridostigmine 、 Somatostatin 、 Growth hormone–releasing hormone 、 Internal medicine 、 Endocrinology 、 Radioimmunoassay 、 Myotonic dystrophy 、 Medicine
摘要: Frequent endocrine alterations and abnormal growth hormone (GH) secretion have been reported in myotonic dystrophy (MD). To evaluate GH status MD, response to 100 micrograms of releasing (GHRH) with or without pyridostigmine pretreatment its relation insulin-induced hypoglycemia was investigated MD patients compared normal controls. The mean peak plasma GHRH 27.8 +/- 19.2 micrograms/l subjects 11.4 8.7 patients. In five seven reached a 12.6 4.2 after hypoglycemia, 5 2.8 GHRH. Conversely, two 16.1 32 GHRH, only 2.5 5.3, respectively, hypoglycemia. Pretreatment nine tested potentiated GHRH-induced release 17.6 12.5 micrograms/l, 10.05 6.7 alone; IGF-I levels were all
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