The protective effect of growth hormone on Cu/Zn superoxide dismutase-mutant motor neurons
作者： Jin-Young Chung , Hyun-Jung Kim , Manho Kim
DOI: 10.1186/S12868-015-0140-Z
关键词:
摘要: Background Amyotrophic lateral sclerosis (ALS) is characterized by selective degeneration of motor neurons. The gene encoding Cu/Zn superoxide dismutase (SOD1) responsible for 20% familial ALS cases. Growth hormone (GH) concentrations are low in the cerebrospinal fluid patients with ALS; however, its association motoneuronal death not known. We tested neuroprotective effects GH on human SOD-1-expressing cultured neurons and SOD1G93A transgenic mice.
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