Prognostic relevance of global histone 3 lysine 9 acetylation in ependymal tumors.
作者： Azadeh Ebrahimi , Jens Schittenhelm , Juergen Honegger , Hermann Schluesener
关键词: Immunohistochemistry 、 Acetylation 、 Biology 、 Neoplasm Grading 、 Cancer research 、 Survival analysis 、 Epigenetics 、 Glioma 、 Histone 、 Ependymoma
摘要: Object Ependymal tumors are highly variable in clinical and molecular behavior affect both children adults. Regarding the paucity of appropriate experimental models, underlying mechanisms their behavioral variability poorly understood. Considering increasing evidence epigenetic changes various tumors, addition to preclinical success epigenetic-based therapeutics CNS, study ependymal is warranted. Methods Using immunohistochemistry, authors investigated patterns global acetylation lysine position 9 histone 3 (H3K9Ac), an marker active gene transcription, 85 with WHO grades clinicopathological characteristics. Results Most nuclei all were H3K9Ac negative (mean ± SD 65.9% 26.5 vs 34.1% 26.5% positive, p < 0.0001). Subependymomas had more H3K9Ac-positive (67.2% 10.2%) than myxopapillary ependymomas, anapla...
sci-hub.se 参考文章(49)
Andrey Korshunov, Andrey Golanov, Valery Timirgaz, Immunohistochemical markers for prognosis of ependymal neoplasms. Journal of Neuro-oncology. ,vol. 58, pp. 255- 270 ,(2002) , 10.1023/A:1016222202230
Adrian M. Dubuc, Stephen Mack, Alexander Unterberger, Paul A. Northcott, Michael D. Taylor, The epigenetics of brain tumors. Methods of Molecular Biology. ,vol. 863, pp. 139- 153 ,(2012) , 10.1007/978-1-61779-612-8_8
Carla Sawan, Zdenko Herceg, Histone modifications and cancer. Advances in Genetics. ,vol. 70, pp. 57- 85 ,(2010) , 10.1016/B978-0-12-380866-0.60003-4
Manel Esteller, Epigenetics in Cancer The New England Journal of Medicine. ,vol. 358, pp. 1148- 1159 ,(2008) , 10.1056/NEJMRA072067
Junli Zhou, Xiangfeng Wang, Kun He, Jean-Benoit F. Charron, Axel A. Elling, Xing Wang Deng, Genome-wide profiling of histone H3 lysine 9 acetylation and dimethylation in Arabidopsis reveals correlation between multiple histone marks and gene expression Plant Molecular Biology. ,vol. 72, pp. 585- 595 ,(2010) , 10.1007/S11103-009-9594-7
Yuan Yao, Stephen C. Mack, Michael D. Taylor, Molecular genetics of ependymoma Chinese Journal of Cancer. ,vol. 30, pp. 669- 681 ,(2011) , 10.5732/CJC.011.10129
Stephen C. Mack, Michael D. Taylor, The genetic and epigenetic basis of ependymoma. Childs Nervous System. ,vol. 25, pp. 1195- 1201 ,(2009) , 10.1007/S00381-009-0928-1
Robert A Johnson, Karen D Wright, Helen Poppleton, Kumarasamypet M Mohankumar, David Finkelstein, Stanley B Pounds, Vikki Rand, Sarah ES Leary, Elsie White, Christopher Eden, Twala Hogg, Paul Northcott, Stephen Mack, Geoffrey Neale, Yong-Dong Wang, Beth Coyle, Jennifer Atkinson, Mariko DeWire, Tanya A Kranenburg, Yancey Gillespie, Jeffrey C Allen, Thomas Merchant, Fredrick A Boop, Robert A Sanford, Amar Gajjar, David W Ellison, Michael D Taylor, Richard G Grundy, Richard J Gilbertson, None, Cross-species genomics matches driver mutations and cell compartments to model ependymoma Nature. ,vol. 466, pp. 632- 636 ,(2010) , 10.1038/NATURE09173
J. Schittenhelm, G. Reifenberger, R. Ritz, T. Nägele, M. Weller, G. Pantazis, D. Capper, R. Beschorner, R. Meyermann, M. Mittelbronn, Primary anaplastic ganglioglioma with a small-cell glioblastoma component. Clinical Neuropathology. ,vol. 27, pp. 91- 95 ,(2008) , 10.5414/NPP27091
Agda KB Lucio-Eterovic, Maria AA Cortez, Elvis T Valera, Fabio JN Motta, Rosane GP Queiroz, Helio R Machado, Carlos G Carlotti, Luciano Neder, Carlos A Scrideli, Luiz G Tone, None, Differential expression of 12 histone deacetylase ( HDAC ) genes in astrocytomas and normal brain tissue: class II and IV are hypoexpressed in glioblastomas BMC Cancer. ,vol. 8, pp. 243- 243 ,(2008) , 10.1186/1471-2407-8-243