Asymmetrical transport of amino acids across the blood-brain barrier in humans.
作者： G. Moos Knudsen , K. D. Pettigrew , C. S. Patlak , M. M. Hertz , O. B. Paulson
关键词: Amino acid 、 Barrier permeability 、 Blood–brain barrier 、 Chemistry 、 Biochemistry
摘要: Blood–brain barrier permeability to four large neutral and one basic amino acid was studied in 30 patients with the double indicator technique. The resultant 64 venous outflow curves were analyzed ...
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C Cangiano, P Cardelli-Cangiano, J H James, F Rossi-Fanelli, M A Patrizi, K A Brackett, R Strom, J E Fischer, Brain microvessels take up large neutral amino acids in exchange for glutamine. Cooperative role of Na+-dependent and Na+-independent systems. Journal of Biological Chemistry. ,vol. 258, pp. 8949- 8954 ,(1983) , 10.1016/S0021-9258(18)32149-5
T B Choi, W M Pardridge, Phenylalanine transport at the human blood-brain barrier. Studies with isolated human brain capillaries. Journal of Biological Chemistry. ,vol. 261, pp. 6536- 6541 ,(1986) , 10.1016/S0021-9258(19)84595-7
P. H. Hutson, G. S. Sarna, B. D. Kantamaneni, G. Curzon, Monitoring the Effect of a Tryptophan Load on Brain Indole Metabolism in Freely Moving Rats by Simultaneous Cerebrospinal Fluid Sampling and Brain Dialysis Journal of Neurochemistry. ,vol. 44, pp. 1266- 1273 ,(1985) , 10.1111/J.1471-4159.1985.TB08753.X
Albert Gjedde, Ove Christensen, Estimates of Michaelis-Menten Constants for the Two Membranes of the Brain Endothelium Journal of Cerebral Blood Flow & Metabolism. ,vol. 4, pp. 241- 249 ,(1984) , 10.1038/JCBFM.1984.33
David L. Yudilevich, Norina De Rose, Francisco V. Sepúlveda, Facilitated transport of amino acids through the blood-brain barrier of the dog studied in a single capillary circulation Brain Research. ,vol. 44, pp. 569- 578 ,(1972) , 10.1016/0006-8993(72)90319-8
Gitte Moos Knudsen, Karen D. Pettigrew, Olaf B. Paulson, Marianne M. Hertz, Clifford S. Patlak, Kinetic analysis of blood-brain barrier transport of D-glucose in man: quantitative evaluation in the presence of tracer backflux and capillary heterogeneity. Microvascular Research. ,vol. 39, pp. 28- 49 ,(1990) , 10.1016/0026-2862(90)90057-X
A. Betz, G. Goldstein, Polarity of the blood-brain barrier: neutral amino acid transport into isolated brain capillaries. Science. ,vol. 202, pp. 225- 227 ,(1978) , 10.1126/SCIENCE.211586
Ivan Tayarani, Jeanne-Marie Lefauconnier, Françoise Roux, Jean-Marie Bourre, Evidence for an Alanine, Serine, and Cysteine System of Transport in Isolated Brain Capillaries Journal of Cerebral Blood Flow and Metabolism. ,vol. 7, pp. 585- 591 ,(1987) , 10.1038/JCBFM.1987.109
Halvor N. Christensen, Developments in amino acid transport, illustrated for the blood-brain barrier. Biochemical Pharmacology. ,vol. 28, pp. 1989- 1992 ,(1979) , 10.1016/0006-2952(79)90213-2
JES OLESEN, OLAF B. PAULSON, NIELS A. LASSEN, Regional Cerebral Blood Flow in Man Determined by the Initial Slope of the Clearance of Intra-arterially Injected l33Xe Stroke. ,vol. 2, pp. 519- 540 ,(1971) , 10.1161/01.STR.2.6.519