Bioresorbable ureteral stents from natural origin polymers
作者： Alexandre A. Barros , Ana Rita , C. Duarte , Ricardo A. Pires , Belém Sampaio‐Marques
DOI: 10.1002/JBM.B.33237
关键词: Materials science 、 Klebsiella oxytoca 、 Stent 、 Gellan gum 、 Swelling 、 Ureteral stents 、 Biomedical engineering 、 Gelatin 、 Polymer 、 Artificial urine
摘要: In this work, stents were produced from natural origin polysaccharides. Alginate, gellan gum, and a blend of these with gelatin used to produce hollow tube (stents) following combination templated gelation critical point carbon dioxide drying. Morphological analysis the surface was carried out by scanning electron microscopy. Indwelling time, encrustation, stability in artificial urine solution up 60 days immersion. vitro studies simulated demonstrated that tubes present high fluid uptake ability, about 1000%. Despite this, materials are able maintain their shape do not an extensive swelling behavior. The bioresorption profile observed be highly dependent on composition stent it can tuned. Complete dissolution may occur between 14 days. Additionally, no encrustation within tested timeframe. ability resist bacterial adherence evaluated Gram-positive Staphylococcus aureus two Gram-negatives Escherichia coli DH5 alpha Klebsiella oxytoca. For K. oxytoca, differences comparison commercial (Biosoft(®) duo, Porges), although, for S. all compositions had higher inhibition adhesion compared stents. case E. coli, addition formulations reduced significant manner developed technology fulfill requirements ureteral will contribute development biocompatible bioresorbable urinary
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