Notch, apoptosis and cancer.

摘要: Proper embryonic development and normal tissue homeostasis require a series of molecular processes, regulating cell growth, differentiation apoptosis. Perturbation in any these processes invariably contributes to the cancer. In particular, defects apoptosis are seen virtually all types human cancers. The Notch pathway plays an important role fate determination both organ homeostasis. Not surprisingly, also cancer when it is dysregulated. this chapter, we will explore how signaling interacts with key pathways that regulate Particularly, focus on relationship between proteins responsible for activation caspase pathway. regulates through extensive networks, involving cycle, growth survival pathways. Thus, examine modulated by crosstalk other such as p53, NF-κB PI3K-Akt