Role of CSL-dependent and independent Notch signaling pathways in cell apoptosis
作者： Chong Zeng , Rui Xing , Jing Liu , Feiyue Xing
DOI: 10.1007/S10495-015-1188-Z
关键词: Cyclin-dependent kinase 8 、 Cell 、 Autocrine signalling 、 Signal transduction 、 Biology 、 Hes3 signaling axis 、 Cell biology 、 Cell signaling 、 Notch proteins 、 Notch signaling pathway
摘要: Apoptosis is a normally biological phenomenon in various organisms, involving complexly molecular mechanisms with series of signaling processes. Notch found evolutionarily conserved many species, playing critical role embryonic development, normal tissue homeostasis, angiogenesis and immunoregulation. The focus this review on currently novel advances about roles CSL-dependent independent Notch pathways cell apoptosis. The CSL can bind intracellular domain (NIC) to act as switch mediating transcriptional activation or inactivation the pathway downstream genes nucleus. It shows that regulates apoptosis through Hes-1-PTEN-AKT-mTOR signaling, but rather CSL-independent mediates possibly via NIC-mTORC2-AKT-mTOR providing new insight into apoptotic mechanisms.
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