Debris of "dark" (compacted) neurones are removed from an otherwise undamaged environment mainly by astrocytes via blood vessels

摘要: By means of a condenser-discharge electric shock paradigm, “dark” granule neurones were momentarily produced in sporadic distribution among normal ones the otherwise undamaged (non-necrotic, non-excitotoxic, non-inflammatory or non-contused) hippocampal dentate gyri rat brain. In electron microscope, ultrastructural elements affected remained but turned markedly electron-dense and distances between them became strikingly reduced (compaction). A proportion such recovered 1 day while others died. During first week survival, dead retained compacted ultrastructure, underwent cytoplasmic convolution fragmentation. The fragments enclosed by membranes separated from each other intact neuropil astrocytic processes containing an excess glycogen particles. Neither proliferation microglial cells nor infiltration haematogenous macrophages was observed. few taken over resting cells, majority engulfed astrocytes. latter transported fragments, either unchanged digested to various degrees, capillaries, arterioles venules. Thereafter, astrocyte-engulfed neuronal as well their partly completely remnants, transferred phagocytotic pericytes discharged into vascular lumina.