Micrometastases in breast cancer: long-term follow-up of the first patient cohort.
作者： D.P. Dearnaley , M.G. Ormerod , J.P. Sloane
DOI: 10.1016/0277-5379(91)90504-7
关键词: Mammary gland 、 Internal medicine 、 Cohort 、 Disease 、 Immunocytochemistry 、 Bone marrow 、 Metastasis 、 Long term follow up 、 Gastroenterology 、 Medicine 、 Breast cancer 、 Pathology
摘要: “Micrometastases” can be identified in the bone marrow of patients with apparently localised breast cancer using an immunocytochemical stain for epithelial membrane antigen (EMA). Of 39 women who had samples examined at time initial presentation (37), or locally recurrent disease (2), 13 (33%) which contained small numbers EMA positive cells. 10 out 23 (44%) lymph-node were positive, compared to 1 14 (7%) lymph node negative cases (P = 0.03). Long-term follow-up (median 9.5 years) has shown that 11 (85%) micrometastases have developed metastatic 8 26 (31%) aspirates < 0.05). The number cells detected probably reflects high potential primary cancers rather than established microscopic deposits; it is not yet clear whether finding such will act as independent variable prognostic factors.
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