Folate and homocysteine interrelationships including genetics of the relevant enzymes

摘要: PURPOSE OF REVIEW Inadequate folate status has been linked to risk of a wide range adverse health conditions throughout life, from birth defects and complications pregnancy cardiovascular disease, cancer cognitive dysfunction in the elderly. In many instances these risks are manifested through elevated plasma homocysteine. This review focuses on current research into contribution genetic variability disease predisposition. RECENT FINDINGS Some dozen potentially important polymorphisms folate-related genes have examined for associations or their role determining level most instances, effects either modest, not significant, undetectable. However, mechanism by which 677C-->T variant methylenetetrahydrofolate reductase determines homocysteine become clearer with elucidation critical riboflavin modulating TT homozygotes. Moreover, several new metaanalyses confirmed an association this vascular probably low SUMMARY There enormous difficulties attempting assess minor nutrient status, against major background differences due ethnicity, age, gender, lifestyle, dietary habits status. Nevertheless, is goal future management chronic multifactorial disease. The present components paving way towards eventual capacity ensure optimal every individual and, consequently, reduce developing such diseases.